USC vs. Notre Dame prediction, odds, line: 2022 Week 13 college football picks, best bets by proven model – CBS Sports

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Rivals square off at Los Angeles Memorial Coliseum on Saturday evening. The No. 6 USC Trojans host the No. 15 Notre Dame Fighting Irish in the regular season finale for both programs. Notre Dame is 8-3 and on a four-game winning streak. USC is 10-1 overall and 6-0 at home, with an appearance in the Pac-12 Championship Game looming next week.

Kickoff is at 7:30 p.m. ET in Los Angeles. Caesars Sportsbook lists the Trojans as 5-point home favorites, while the over/under, or total number of points Vegas thinks will be scored, is 64.5 in the latest Notre Dame vs. USC odds. Before making any USC vs. Notre Dame picks, be sure to check out the college football predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on USC vs. Notre Dame and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Now, here are several college football odds and trends for Notre Dame vs. USC:

  • Notre Dame vs. USC spread: USC -5
  • Notre Dame vs. USC over/under: 64.5 points
  • Notre Dame vs. USC money line: USC -210, ND +175
  • ND: The Irish are 6-5 against the spread this season
  • USC: The Trojans are 7-4 against the spread this season
  • Notre Dame vs. USC picks: See picks at SportsLine
Featured Game | USC Trojans vs. Notre Dame Fighting Irish

Why Notre Dame can cover

Notre Dame has the superior defense in this matchup. The Fighting Irish, led by Marcus Freeman, are allowing only 20.3 points per game, and Notre Dame is in the top 20 of FBS in total yards allowed (317.2 per game). Notre Dame is above-average against the pass and the run, with the Irish giving up fewer than 190 passing yards per game. Opponents are completing only 56.5% of pass attempts against Notre Dame, with the Fighting Irish producing 33 sacks, a top-15 mark in the nation. 

Junior defensive lineman Isaiah Foskey is in the top 10 of FBS with 9.5 sacks, and Notre Dame is holding opponents to a 34% third down efficiency rate. On the other side, USC is allowing 405 total yards per game, including 257.8 passing yards per contest, and the Trojans are giving up 4.6 yards per carry.

Why USC can cover

USC is absolutely rolling on offense this season, leading to a potential path toward the College Football Playoff. The Trojans are averaging 42.9 points per game, No. 3 among FBS teams this season. USC has scored 40 points or more in five consecutive games, and the Trojans have a school-record with nine games with at least 40 points. The Trojans are No. 2 in the country with 513.0 total yards per game, and USC is No. 4 in the country in passing offense, producing 330.8 yards per game through the air. 

USC is in the top ten of the country with 9.1 yards per pass attempt, and the team has 34 passing touchdowns and only three interceptions this season. Caleb Williams is a Heisman Trophy candidate at quarterback, and USC also has a potent running game. The Trojans are averaging 182.2 rushing yards per game, a top-five mark in the Pac-12, and USC is averaging 5.3 yards per carry. In addition to explosiveness, USC is highly efficient with the No. 2 mark in the nation in third down efficiency at 54.3%.

How to make USC vs. Notre Dame picks

SportsLine’s model is leaning Under on the total, projecting the teams to combine for 61 points. The model also says one side of the spread hits well over 50% of the time. You can only get the model’s pick at SportsLine

So who wins Notre Dame vs. USC? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.